Clinical Cases Glioblastoma multiforme

Glioblastoma multiforme

Jenny is a 29-year-old elementary school teacher. For the past 2 weeks she has been experiencing "really bad" headaches. She has a history of migraines but the medication she normally takes is "not helping at all". Yesterday Jenny had a hiccupping episode that lasted approximately 15 hours. After describing her symptoms to her husband they decided to head to the local emergency room. Subsequent imaging studies confirmed a diagnosis of Glioblastoma multiforme.

1. Glioblastoma Multiforme is a malignant, high-grade tumor of: (Please click on the best answer choice below)
   
   • Oligodendrocytes
   • Astrocytes
   • Ependymal cells
   • Microglia
   • Satellite cells

   Correct

   Incorrect

2. Glioblastoma multiforme is the most common primary malignant CNS tumor in adults, commonly arising in the cerebellum. (Please click on the best answer choice below)
   
   • True
   • False

   Correct

   Incorrect

   Feedback:
   It normally arises in the cerebral hemisphere and characteristically crosses the corpus callosum producing a "butterfly lesion" appearance

3. Glioblastoma is characterized by: (Please click on the best answer choice below)
   
   • Involvement of cranial nn and most frequently involving cranial nerve VIII at the cerebellopontine angle

     (Wrong this is describing a Schwannoma)

   • Tumor cells that are S-100 positive

     (wrong- also a Schwannoma)

   • "Fried egg" appearance of cells on biopsy

     (wrong- this is Oligodendroglia)

   • Regions of necrosis surrounded by tumor cells "pseudopalisading".
   • Rosenthal fibers on biopsy (Wrong- this is Pilocytic Astrocytoma

   Correct

   Incorrect

   It also exibits endothelial cell proliferation and tumor cells are GFAP positive, this is a special stain for astrocytes and ependymal cells

CONTINUE